Clinical Trial

Deep Brain Stimulation for Treatment Resistant Depression

Study Description

Deep Brain Stimulation for Treatment Resistant Depression

Treatment resistant depression (TRD) is a major global health concern, and there is a crucial need to develop novel effective treatments. The medial forebrain bundle (MFB) is a recently described DBS target, with reported rapid onset of antidepressant effects. A recent small randomized trial reported a 100% response rate. The subcallosal cingulate cortex (SCC) is the most commonly used target in DBS for depression. Herein, the investigators will conduct a sham-controlled randomized trial of DBS to the MFB or SCC for TRD.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Device - Active stimulation of the medial forebrain bundle or subcallosal cingulate

Deep brain stimulation of the medial forebrain bundle or subcallosal cingulate

Device - Sham stimulation

Sham stimulation for 2 weeks (Cross-over design)

Additional Information

Official Study Title

Deep Brain Stimulation of the Medial Forebrain Bundle and Subcallosal Cingulate for the Treatment of Treatment Resistant Depression

Clinical Trial ID

NCT04009928

ParticipAid ID

e5yv8e