Clinical Trial

Dopaminergic Mechanisms Underlying Human Social Behavior

Study Description

Dopaminergic Mechanisms Underlying Human Social Behavior

Developing theoretical, quantitative models of the basic cognitive mechanisms underlying human social decision-making, and understanding the influence of neuromodulators such as dopamine on these mechanisms, has important ramifications for both healthy and patient populations. In this proposal we combine quantitative social measures, computational models, neuroimaging, and a pharmacological intervention to define the mechanisms of social decision-making.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Tolcapone 200 MG

Tolcapone is a brain penetrant catechol-O-methyltransferase (COMT) inhibitor. It will be administered in randomized, double-blind, counterbalanced fashion with a placebo.

Functional Magnetic Resonance Imaging (fMRI)

FMRI provides an indirect and noninvasive measure of brain activity.

Additional Information

Official Study Title

Dopaminergic Mechanisms Underlying Human Social Behavior: A Multimodal Approach

Clinical Trial ID

NCT04205994

ParticipAid ID

e9rkPa