“Dopaminergic Mechanisms Underlying Human Social Behavior”
Developing theoretical, quantitative models of the basic cognitive mechanisms underlying human social decision-making, and understanding the influence of neuromodulators such as dopamine on these mechanisms, has important ramifications for both healthy and patient populations. In this proposal we combine quantitative social measures, computational models, neuroimaging, and a pharmacological intervention to define the mechanisms of social decision-making.
Drug - Tolcapone 200 MG
Tolcapone is a brain penetrant catechol-O-methyltransferase (COMT) inhibitor. It will be administered in randomized, double-blind, counterbalanced fashion with a placebo.
Functional Magnetic Resonance Imaging (fMRI)
FMRI provides an indirect and noninvasive measure of brain activity.
Dopaminergic Mechanisms Underlying Human Social Behavior: A Multimodal Approach