“PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2”
PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) is a Phase III randomized, controlled, double blinded multicenter trial with 3 parallel groups (Ketotifen 2 mg or 5 mg or lactose placebo twice daily orally for 6 weeks) and a primary endpoint of elbow extension-flexion range of motion (ROM) arc at 12 weeks post-randomization.
Drug - Lactose Placebo
One capsule by mouth twice per day
Drug - Ketotifen Fumarate 2mg
2 mg tablets (over-encapsulated into one capsule) by mouth twice per day
Drug - Ketotifen Fumarate 5mg
5 mg tablets (over-encapsulated into one capsule) by mouth twice per day
PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2
NCT03582176
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