Preventing Posttraumatic Joint contractuRes with Ketotifen 2

Eligibility Details: Inclusion Criteria: - Age ≥ 18 years old; skeletally mature with no growth plates in the elbow - Distal humerus (AO/OTA type 13) and/or proximal ulna and/or proximal radius fractures (AO/OTA type 2U1 or 2R1) and/or elbow dislocations (open fractures with or without nerve injury may be included) - Operative treatment of the elbow fracture or dislocation - Injury ≤ 7 days - Participant has a negative urine or blood serum pregnancy test Exclusion Criteria: - Pre-existing elbow contracture - Elbow arthritis (osteoarthritis, inflammatory arthritis, or nonspecific monoarticular arthritis) - Inability to mobilize elbow within 21 days of injury - Bilateral elbow injury - Concomitant musculoskeletal or visceral injuries preventing post-operative elbow therapy - Oral hypoglycemic medications - History of epilepsy - Lactose intolerance - Language or Cognitive difficulties preventing reliable completion of questionnaires - Females who are pregnant or breast feeding - Females of reproductive age or males unwilling to use 2 effective methods of contraception - Severe renal impairment - Severe hepatic impairment - Prior elbow injury or operation - Total elbow replacement planned for treatment of injury - Unlikely to maintain follow up (no fixed address, plans to move out of town in the next year, states unable to comply with protocol) - Unwilling or unable to provide written informed consent for trial participation