Eligibility Details:
Inclusion Criteria:
- Age of # 18 <36. - Right-handed.
- Be in good health determined by the investigator on basis of medical history, physical
and neurological exam; for "EEG-only" sessions no physical or neurological exams will
be performed;
- Female subjects must be two years past menopause, surgically sterile or practicing a
medically acceptable method of birth control (does not apply to "EEG-only" sessions);
- Female subjects must not be pregnant.
- Able to understand and speak English.
- Able to provide written consent prior to admission
Exclusion Criteria:
- History of epilepsy, stroke, brain surgery, cranial metal implants, structural brain
lesion, devices that may be affected by TMS or tCS(pacemaker, medication pump,
cochlear implant, implanted brain stimulator); - Women who are breast-feeding (self
report)*;
- History of head trauma with loss of consciousness for greater than 5 minutes;
- Any history of seizures;
- Any family history of seizures*;
- Diabetes requiring insulin treatment*;
- A serious heart disorder or subjects who have had a heart attack within the last 3
months;
- Subjects who meet DSM-IV criteria for alcohol /drug abuse problems within the last six
months;
- Any current Axis I or II diagnoses or past Axis I diagnoses;
- Required use of medication that affects CNS function;
- A subject with metallic implants, such as prostheses, shrapnel or aneurysm clip-S, or
persons with electronic implants, such as cardiac pacemakers. The magnetic field
generated by the MR machine can cause a displacement or malfunctioning of these
devices*;
- The female subject who is pregnant or planning to become pregnant; or a female subject
of child-bearing potential who is not practicing a medically acceptable form of birth
control*;
- The subject has had a diagnosis of cancer in the past 3 years and/or has active
neoplastic disease;
- The investigator anticipates that the subject will be unable to comply with the
protocol.
- Prohibited Concomitant Treatment: Any investigational medication; antipsychotic,
antidepressant; or ECT; Other psychotropic medications including sedative hypnotics
(excluding chloral hydrate zaleplon); sumatriptan (and similar agents); anxiolytics
and herbals (e.g., St. John's Wort, Kava Kava); an introduction or change in intensity
of psychotherapy; any nonpsychopharmacologic drug with psychotropic effects (e.g.,
antihistamines, beta blockers).
- Colorblindness
- Poor or Uncorrected Vision
- History of fainting/syncope