“The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction”
The goal of this study is to examine possible mechanisms of heightened vasoconstriction in Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.
Drug - Control (Phenylephrine)
This intervention is aimed at assessing the vascular responsiveness to phenylephrine, an alpha 1-agonist, in white and black men and women across a series of ascending dose concentrations.
Drug - Phenylephrine + Apocynin
This intervention is meant to assess the impact of NADPH oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme NADPH oxidase.
Drug - Phenylephrine + Allopurinol
This intervention is meant to assess the impact of xanthine oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme xanthine oxidase.
Drug - Phenylephrine + Tempol
This intervention is meant to assess the impact of superoxide on vasoconstrictor responses by scavenging available superoxide.
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
NCT03680404
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