Clinical Trial

Racial Differences in Vasoconstriction

Study Description

The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction

The goal of this study is to examine possible mechanisms of heightened vasoconstriction in Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Control (Phenylephrine)

This intervention is aimed at assessing the vascular responsiveness to phenylephrine, an alpha 1-agonist, in white and black men and women across a series of ascending dose concentrations.

Drug - Phenylephrine + Apocynin

This intervention is meant to assess the impact of NADPH oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme NADPH oxidase.

Drug - Phenylephrine + Allopurinol

This intervention is meant to assess the impact of xanthine oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme xanthine oxidase.

Drug - Phenylephrine + Tempol

This intervention is meant to assess the impact of superoxide on vasoconstrictor responses by scavenging available superoxide.

Additional Information

Official Study Title

The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction

Clinical Trial ID

NCT03680404

ParticipAid ID

egJnYd