Clinical Trial

Low INR to Minimize Bleeding with Mechanical Valves Trial

Study Description

Low INR to Minimize Bleeding With Mechanical Valves Trial

This study evaluates the use of a lower INR target (1.5 to 2.5) in patients with a mechanical heart valve in the aortic position. This study will inform physicians about whether a lower INR target will decrease the risk of bleeding or increase the risk of blood clot formation and stroke. These results have the potential to reduce the burden of bleeding in patients with a mechanical heart valve who require lifelong warfarin (Coumadin) treatment.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Drug - Warfarin

Participants in both arms will be on warfarin therapy post-mechanical valve replacement as is standard, but will have different INR target ranges.

Additional Information

Official Study Title

Low INR to Minimize Bleeding With Mechanical Valves Trial - Vanguard

Clinical Trial ID

NCT03636295

ParticipAid ID

elY5ga