Low INR to Minimize Bleeding with Mechanical Valves Trial
Study Description
“Low INR to Minimize Bleeding With Mechanical Valves Trial”
This study evaluates the use of a lower INR target (1.5 to 2.5) in patients with a mechanical heart valve in the aortic position. This study will inform physicians about whether a lower INR target will decrease the risk of bleeding or increase the risk of blood clot formation and stroke. These results have the potential to reduce the burden of bleeding in patients with a mechanical heart valve who require lifelong warfarin (Coumadin) treatment.
Location
Methods
Pharmaceutical medication involved
Recruiting patients only
Drug - Warfarin
Participants in both arms will be on warfarin therapy post-mechanical valve replacement as is standard, but will have different INR target ranges.
Additional Information
Official Study Title
Low INR to Minimize Bleeding With Mechanical Valves Trial - Vanguard
Clinical Trial ID
NCT03636295
ParticipAid ID
elY5ga
