Clinical Trial

Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty

Study Description

Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty

The purpose of this research is to understand whether patients who previously had total hip or total knee replacement experience memory, thinking or heart problems. This study will help us determine if and how often these problems occur.


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No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Behavioral - Questionnaires

You will be asked to complete a questionnaire about your family history of neurological diseases and current and past physical thinking activities.

Behavioral - Interviews

Behavioral and Memory interviews will take place with the patient.

Blood draw

Have a sample of blood drawn (4.2-5 tablespoons) for clinical and research tests.

Radiation - Magnetic Resonance Imaging

Each MR examination takes about 45 minutes and does not require the use of needles, medication or contrast enhancement. You will lie on your back and enter the MR scanner for the study, during which time you will hear knocking noises. People with pacemakers, aneurysm clips, cochlear implants, or metal/foreign objects in their eyes are not permitted to undergo MR studies. We will review your implants and determine your eligibility.

Diagnostic Test - Echocardiogram

Each echocardiogram takes about 30 minutes. This test uses sound waves to look at your heart. The person doing the test will press on your chest with a machine to obtain the pictures. The pressure may be uncomfortable. The echocardiogram will involve an image enhancement agent infusion to obtain better images.

Additional Information

Official Study Title

Risk of Dementia and Heart Failure in Total Joint Arthroplasty

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