Clinical Trial

Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet

Study Description

Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet

Evaluation of the pharmacokinetics for [14C]-benzo[a]pyrene ([14C]-BaP) and metabolites in plasma and urine over 48 hours following a 50 ng dose (5.4 nCi) alone, following 7 days' consumption of Brussels sprouts, and following 7 days' consumption of a supplement containing 3,3'-diindolylmethane (DIM).

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - [14C]-benzo[a]pyrene

Oral micro-dose (50 ng) (5.4 nCi)

Drug - Brussels sprouts before 50 ng dose

Brussels sprouts for 7 days before 50 ng (5.4 nCi) dose of BaP

Drug - DIM supplement before 50 ng dose

DIM supplement for 7 days before 50 ng (5.4 nCi) dose of BaP and coadministration with DIM supplement

Additional Information

Official Study Title

Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet

Clinical Trial ID

NCT03802721

ParticipAid ID

erkBka