Clinical Trial

Supplementation of a Leucine-Enriched Protein Blend

Study Description

Supplementation of a Leucine-enriched Protein Blend

It is well known that dietary protein transiently stimulates muscle protein synthesis (MPS) whereby changes in MPS in response to feeding may be regulated by specific downstream target proteins of mammalian target of rapamycin signaling, such as S6K1, rpS6, and eIF2B. A meal deficient in protein, however, does not increase the rate of MPS because a rise in the bioavailability of amino acids does not occur. In addition, the source of dietary proteins has been shown to impact postprandial blood levels of amino acids. The concept that certain types of proteins are "fast acting" or "slow acting" has been shown to affect the postprandial profile of amino acids appearing in the systemic circulation. Native whey and micellar casein are both dairy proteins that contain a similar amount of essential (EAA), but blood EAA levels increase faster and to a higher level after the consumption of whey protein. Differences in gastric emptying, digestion and absorption kinetics between micellar casein and native whey are the underlying factors. Nonetheless, micellar casein protein has been shown to protract MPS in humans. Despite the significant amount of information gained with respect to both of these protein sources, the effects of combinatorial formulations on the postprandial profile of amino acids appearing in the blood is less well known.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Dietary Supplement - Leucine-enriched protein

Supplement contains 16g of protein given twice per exercise session (4 total exercise sessions)

Behavioral - Habitual diet only

Habitual diet only (no supplementation) for 4 exercise sessions

Additional Information

Official Study Title

Supplementation of a Leucine-Enriched Dairy Protein Blend: Chronic and Acute Metabolic Responses in Young Men and Women

Clinical Trial ID

NCT03796897

ParticipAid ID

erkXwa