Clinical Trial

Itraconazole Oral Absorption

Study Description

Itraconazole Oral Absorption

For tablets to be absorbed, the drug must dissolve after being swallowed. Drugs with low solubility sometimes require the inert ingredients in tablets to help the drug dissolve after being swallowed. This study uses itraconazole as an example drug with low solubility. Itraconazole tablets with different inert ingredients and manufacturing will be administered to healthy volunteers to see if the different inert ingredients and manufacturing impact drug absorption.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - fast itraconazole tablet

100mg dose

Drug - medium itraconazole tablet

100mg dose

Drug - slow itraconazole tablet

100mg dose

Drug - oral itraconazole solution

100mg dose

Additional Information

Official Study Title

Prediction of Itraconazole Oral Absorption From In Vitro Dissolution

Clinical Trial ID

NCT04035187

ParticipAid ID

erkr4a