“Alternation in the Human Microbiome With Commonly Used Topical Medications”
The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients. The specific aims are as follows: 1. Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use. 2. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.
Drug - Desonide 0.05%
Desonide 0.05% ointment topically twice daily for two weeks
Drug - Ketoconazole 2%
Ketoconazole 2% cream topically twice daily for two weeks
Alterations in the Human Microbiome With Commonly Used Topical Medications