Clinical Trial

Endothelin Receptor Function and Acute Stress

Study Description

Endothelin Receptor Function and Acute Stress

Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress. This study is an extension of the investigators previous animal work to evaluate the role of endothelin-1 during stress in humans.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Bosentan

Stress response and vascular function will be assessed 3 days following 125 mg twice per day of Bosentan

Drug - Placebo

Stress response and vascular function will be assessed 3 days following twice per day placebo

Additional Information

Official Study Title

Endothelin Receptor Function and Acute Stress (End-Stress)

Clinical Trial ID

NCT02116335

ParticipAid ID

lej8zb