“Endothelin Receptor Function and Acute Stress”
Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress. This study is an extension of the investigators previous animal work to evaluate the role of endothelin-1 during stress in humans.
Drug - Bosentan
Stress response and vascular function will be assessed 3 days following 125 mg twice per day of Bosentan
Drug - Placebo
Stress response and vascular function will be assessed 3 days following twice per day placebo
Endothelin Receptor Function and Acute Stress (End-Stress)