Clinical Trial

Regulation of Insulin Secretion

Study Description

Regulation of Insulin Secretion by the GLP-1 Receptor

The purpose of this study is to determine the role of basal GLP-1 action on the -cell response to insulin resistance. Healthy subjects will have fasting GLP-1 action determined with GLP-1r blockade before and after induction of experimental insulin resistance. The investigators hypothesize that fasting GLP-1 action will increase to compensate for experimental insulin resistance.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Exendin (9-39)

Upon establishing a hyperglycemic clamp (target blood glucose at basal +3 mM) Exendin (9-39) will be infused.

Drug - Dexamethasone

Between Visit-2 and Visit-3, Dexamethasone (4 mg tablet) once daily for 5-7 days.

Hyperglycemic Clamp

A variable infusion of 20% dextrose will begin to clamp the blood glucose at basal +3 mM.

Additional Information

Official Study Title

Regulation of Insulin Secretion by the GLP-1 Receptor

Clinical Trial ID

NCT02844907

ParticipAid ID

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