Clinical Trial

Polyol Pathway in the Central Nervous System

Study Description

Investigating the Role of the Polyol Pathway in the Central Nervous System

Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia. Subjects will also undergo a lumbar puncture at a separate occasion to assess cerebrospinal fluid levels of metabolites.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Brain MRS during hyperglycemic clamp

All patients will undergo brain MRS at baseline and following 2 and 4 hours of hyperglycemia using the clamp technique

Analysis of Metabolites in cerebrospinal fluid

All patients will have the option to undergo a lumbar puncture for analysis of metabolites in cerebrospinal fluid

Additional Information

Official Study Title

Investigating the Role of Polyol Pathway in the Central Nervous System

Clinical Trial ID

NCT02272556

ParticipAid ID

mbkoYb