“Investigating the Role of the Polyol Pathway in the Central Nervous System”
Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia. Subjects will also undergo a lumbar puncture at a separate occasion to assess cerebrospinal fluid levels of metabolites.
Brain MRS during hyperglycemic clamp
All patients will undergo brain MRS at baseline and following 2 and 4 hours of hyperglycemia using the clamp technique
Analysis of Metabolites in cerebrospinal fluid
All patients will have the option to undergo a lumbar puncture for analysis of metabolites in cerebrospinal fluid
Investigating the Role of Polyol Pathway in the Central Nervous System