“Randomized On-X Anticoagulation Trial”
Various patient groups with the On-X Valve can be maintained safely on lower doses of blood thinner(CoumadinAR) or on antiplatelet drugs (aspirin/PlavixAR) only rather than the standard dose of Coumadin and aspirin presently recommended by ACC/AHA or ACCP professional societies.
Device - On-X valve using reduced anticoagulation
Valve replacement with antiplatelet agents or lowered warfarin
Device - On-X Valve with Standard warfarin Therapy
Valve replacement with standard dosage warfarin
Prospective Randomized On-X Anticoagulation Clinical Trial (PROACT)