Clinical Trial

Postoperative Nausea and Emesis in Gastrectomy

Study Description

Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

Bariatric surgery remains the most effective therapy for obesity. Postoperative nausea and vomiting (PONV) are commonly reported following bariatric surgery. The proposed study focuses on the most common bariatric procedure performed, laparoscopic sleeve gastrectomy (LSG), and aims to assess the effect of a post-operative nausea and vomiting-specific intervention. The investigators hypothesize that the intervention group will experience a reduction of nausea-related prolonged hospital stay and significantly improve patient-reported quality of recovery from surgery and quality of life.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Aprepitant 80Mg Oral Capsule

aprepitant 80 mg orally one hour prior to scheduled surgery

Drug - scopolamine transdermal

scopolamine transdermal patch one hour prior to scheduled surgery

Procedure - Total intravenous anesthesia

Maintenance of anesthesia without the use of inhaled anesthetics.

Drug - Dexamethasone

Dexamethasone 8 mg intraoperatively

Drug - Ondansetron

Ondansetron 4 mg intraoperatively. Ondansetron will be given twice. Once intraoperatively and then post- operatively.

Drug - Reglan

Postoperatively scheduled Reglan

Drug - Ondansetron

Postoperatively scheduled ondansetron

Drug - Compazine

Postoperatively as needed compazine for breakthrough PONV

Drug - Sugammadex

Reversal with sugammadex

Drug - Propofol

Intravenous anesthesuia will be maintained through IV propofol

Drug - dexmedetomidine

maintainance of anesthesia in the intervention arm

Drug - Fentanyl

intermittent bolus dosing of fentanyl will be used after induction for anesthesia maintenance

Drug - Sevoflurane

inhalational anesthesia

Drug - Desflurane

inhalational anesthesia

Additional Information

Official Study Title

Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

Clinical Trial ID

NCT03435003

ParticipAid ID

mepxme