“Prevention of Infections in Cardiac Surgery (PICS) Prevena Study”
This vanguard study will be conducted at two study sites in Canada. It is a cluster randomized trial to test a combination of two antibiotics for antibiotic prophylaxis as compared to routine prophylaxis with one single antibiotic, and to test a negative-pressure wound management system (Prevena) versus standard wound dressing to reduce chest wound infections.
Device - Prevena
Negative-Pressure Wound Management System
Drug - Cefazolin
Drug - Vancomycin
standard wound dressing
Any non-negative pressure wound dressing that is routinely used at study sites will be considered standard of care in the control arms.
A Cluster-randomized Factorial Crossover Trial, Comparing Antibiotic Mono-prophylaxis With Cefazolin vs. Dual-prophylaxis With Cefazolin Plus Vancomycin and Conventional Wound Dressing vs. Prevena Negative-pressure Wound Management