Clinical Trial

Prevention of Infections in Cardiac Surgery

Study Description

Prevention of Infections in Cardiac Surgery (PICS) Prevena Study

This vanguard study will be conducted at two study sites in Canada. It is a cluster randomized trial to test a combination of two antibiotics for antibiotic prophylaxis as compared to routine prophylaxis with one single antibiotic, and to test a negative-pressure wound management system (Prevena) versus standard wound dressing to reduce chest wound infections.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Device - Prevena

Negative-Pressure Wound Management System

Drug - Cefazolin

antibiotic

Drug - Vancomycin

antibiotic

standard wound dressing

Any non-negative pressure wound dressing that is routinely used at study sites will be considered standard of care in the control arms.

Additional Information

Official Study Title

A Cluster-randomized Factorial Crossover Trial, Comparing Antibiotic Mono-prophylaxis With Cefazolin vs. Dual-prophylaxis With Cefazolin Plus Vancomycin and Conventional Wound Dressing vs. Prevena Negative-pressure Wound Management

Clinical Trial ID

NCT03402945

ParticipAid ID

mepyXa