Hyperglycemia and Mitochondrial Function in the Endothelium

Eligibility Details: Inclusion Criteria: 1. Adult age 21 to 70 2. No evidence of metabolic syndrome or diabetes, hypertension (BP≥140/90), or high cholesterol (LDL≥160) at the time of screening. Exclusion Criteria: 1. History of stroke, peripheral arterial disease, or coronary artery disease (as defined by the presence of at least one coronary stenosis ≥ 40% on angiography or by confirmed history of myocardial infarction by standard criteria). 2. History of bleeding disorders. 3. Evidence of other evident major illness including chronic renal insufficiency (plasma creatinine > 1.4 for women or 1.5 for men), liver disease (liver enzymes greater than 2.5 x normal), and cancer 4. currently undergoing therapy or had therapy for cancer within 1 year of enrollment. 5. Pregnancy as determined by urinary human chorionic gonadotropin beta test 6. Thienopyridine, anti-thrombin/Xa, or warfarin therapy at time of screening 7. On medication for cholesterol or blood pressure