Inhibiting Early Inflammation in Kidney Transplant Patients

Eligibility Details: Inclusion Criteria: 1. Adult (>18 years of age) male and female recipients (all races and ethnicities) 2. Subject must be able to understand and provide consent 3. Recipients of deceased donor kidney transplants (including re-transplants) 4. Negative crossmatch, actual or virtual, or a PRA of 0% on historic and current sera as determined by each participating study center 5. Donor kidneys from deceased donors and donors after cardiac death (DCD) with Kidney Donor Profile Indices (KDPI) ranging from ≥20 to <95 6. Female participants of childbearing potential must have a negative pregnancy test upon study entry 7. Subjects must have a negative test result for latent tuberculosis (TB) infection (PPD, QuantiFERON, ELISPOT): - Subjects who have a negative test result for latent TB infection within 1 year of transplant date are eligible for enrollment and no further action is required - Subjects who have a negative test for latent TB infection that is greater than 1 year old are eligible for enrollment but are required to have a repeat test prior to transplantation. Exclusion Criteria: 1. Inability or unwillingness of a participant to give written informed consent or comply with study protocol 2. Recipients of living donor transplants 3. Presence of other transplanted solid organ (heart, lung, liver, pancreas, small intestines) or co-transplanted organ 4. Human immunodeficiency virus positive (HIV+) recipients 5. Epstein-Barr virus Immunoglobulin G (EBV IgG) negative recipients 6. Hepatitis B surface antigen positive kidney transplant recipients 7. Hepatitis B core antibody positive kidney transplant recipients 8. Hepatitis B negative kidney transplant recipients that receive transplants from Hepatitis B core antibody positive donor 9. Hepatitis C Virus positive (HCV+) patients who are either untreated or have failed to demonstrate sustained viral remission for more than 12 months after anti-viral treatment 10. Recipients with a previous history of active TB 11. Recipients with a positive test for latent TB infection (PPD, QuantiFERON, ELISPOT), regardless of previous therapy 12. Any severe infection at the time of transplantation. --Note: Severe infection determination will be made by the local site investigator. 13. Severe congestive heart failure (NYHA functional class III or higher) 14. Subjects with a known hypersensitivity to any murine/ mouse proteins 15. Subjects with any history of receiving any anti-tumor necrosis factor (anti- TNF) products 16. Subjects in whom rabbit anti-thymocyte globulin (Thymoglobulin®) or infliximab might not be tolerated 17. Subjects with a white blood cell count less than 3000/mm^3 18. Subjects with a platelet count less than 100,000/mm^3 19. Subjects with systolic blood pressure <100 mm/Hg 20. Subjects with symptomatic orthostatic hypotension or currently requiring Midodrine for blood pressure support 21. Subjects from, or who have traveled, to endemic areas with a history of active histoplasmosis or, with a chest x-ray consistent with previous active histoplasmosis (no serological testing required) : --Endemic regions determined by site based on local standard of care. 22. Subjects currently or formerly residing in regions of the United States that are highly endemic for coccidioidomycosis, and who have a positive serologic test for coccidioidomycosis: --Endemic regions determined by site based on local standard of care. 23. Recipients are excluded if the local site decides to treat the recipient with fluconazole because of diagnosis or suspicion of fungal infection the donor 24. Subjects that receive IVIG treatment within 3 months of transplant or planned intravenous immunoglobulin (IVIG) treatment peri-transplant 25. Use of an investigational agent within 4-weeks prior to study entry.