Eligibility Details:
Group 1: Healthy Subjects in Sleep Lab:
Inclusion Criteria
- Age 18 or older
- Scheduled for a standard of care polysomnography lasting at least 8 hours for any
condition
Exclusion Criteria
- Patient/Legally Authorized Representative declines consent
Group 2: ICU patient, not sedated, not ventilated
Inclusion Criteria
- Age 18 or older
- Anticipated to stay in intensive care unit overnight (minimum 8 hours)
- Glasgow Coma Scale score of 13 or great
Exclusion Criteria:
- Intubated with endotracheal tube
- Sedated (includes sedative drugs such as propofol, Dexmedetomidine, versed infusion
above 2mg/hr, ketamine infusion above 0.2 mg/kg/hr).
Group 3: ICU patient, sedated and ventilated
Inclusion Criteria:
- Age 18 or older
- Anticipated to stay in the intensive care unit overnight (minimum 8 hours)
- Intubated, sedated, and ventilated
Exclusion Criteria:
- Presence of traumatic brain injury
- Planned extubation in next 8 hours
- Scheduled to leave the intensive care unit for any reason in the next 8 hours
- Anticipated life expectancy of less than 24 hours
- Electroencephalogram monitoring (current or scheduled in the next 8 hours)
- Hemodynamic instability (defined as: (i) mean arterial pressure <60mmHg for >20
minutes with efforts to raise it or (ii) >2 liter fluid administered in 2h after
operating room and anticipating on-going needs for fluid resuscitation or (iii) ICU MD
determination of "atypical and profound hemodynamic instability" or (iv) PI
determination after evaluation.
- Refractory hypoxemia - defined as Saturation <88% on Sp02 despite efforts to increase
it
- Hemorrhage - defined as >500cc chest tube output in 2h and anticipated need of more
than 2 units of packed red blood cells in immediate post op period. This does NOT
include cell-saver.