Clinical Trial

Radiation in Metastatic Lung Cancer

Study Description

Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Treating Patients With Limited Stage or Extensive Stage Small Cell Lung Cancer

This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only (limited stage) or has spread outside of the lung in which it began or to other parts of the body (extensive stage). Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. The hippocampus is part of the brain that is important for memory. Avoiding the hippocampus during whole-brain radiation could decrease the chance of side effects on memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more effective with or without hippocampal avoidance in treating patients with small cell lung cancer.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Radiation - 3-Dimensional Conformal Radiation Therapy

Undergo PCI using 3DCRT

Cognitive Assessment

Ancillary studies

Radiation - Intensity-Modulated Radiation Therapy

Undergo PCI with HA using IMRT

Laboratory Biomarker Analysis

Correlative studies

Quality-of-Life Assessment

Ancillary studies

Additional Information

Official Study Title

Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung Cancer

Clinical Trial ID

NCT02635009

ParticipAid ID

pen7pa