Effect of Exercise on Genes that Control Muscle Function

Eligibility Details: Inclusion Criteria: - Age 20 - 40 years - BMI 18.5 - 29.9 - Stable body weight (not more than 2 kg change) during the past 6 months - Moderate sedentary (regular exercise less than 1 hour per week for the last 6 months) - Willing to provide informed consent Exclusion Criteria: - Failure to provide informed consent - Any major chronic disease or any condition that would interfere with exercise, in which exercise is contraindicated, or that would interfere with interpretation of results - Severe orthopedic and or neuromuscular disease that would contraindicate participation in exercise - Other significant co-morbid disease that would impair ability to exercise - Uncontrolled hypertension (BP greater than 160/90) - History of malignancy during the past 5 years - Diabetes mellitus as determined by self-report with verification (medical records, current treatment, confirmation from health care provider), or HbA1c of exceeding 6.5%