“Fatty Acid Oxidation Defects and Insulin Sensitivity”
The purpose of this study is to learn more about what causes insulin resistance. It has been suggested that proper breakdown of fat into energy (oxidation) in the body is important to allow insulin to keep blood sugar in the normal range. The investigators want to know if having one of the fatty acid oxidation disorders could have an influence on insulin action. Fatty acid oxidation disorders are genetic disorders that inhibit one of the enzymes that converts fat into energy. The investigators will study both normal healthy people and people with a long-chain fatty acid oxidation disorder.
Drug - Intralipid/Heparin
Co-infusion of intralipid and heparin solutions during a hyperinsulinemic euglycemic clamp
Drug - Glycerol/Saline
Co-infusion of a glycerol/saline solutions during a hyperinsulinemic euglycemic clamp
Drug - Hyperinsulinemic euglycemic clamp
Infusion of insulin at at 40 mU/m2/min for 5 hours. Blood glucose will be monitored every 5 min during the insulin infusion and euglycemia will be maintained throughout the clamp by infusing 20% dextrose at a variable rate.
Role of Fatty Acid Oxidation Defects in Insulin Sensitivity