Clinical Trial

The Effect Dialysis on the Pharmacokinetics of Fexofenadine

Study Description

The Effect Dialysis on the Pharmacokinetics of Fexofenadine

The Investigators recently completed and published a study that demonstrated that fexofenadine pharmacokinetics are significantly altered in dialysis patients (Thomson et al. (2015) American Journal of Kidney Diseases 65(4):574-582). In this study, patients were studied directly before routine dialysis treatment. Other published literature suggests the timing of the dose of some drugs (before or after dialysis) may have a profound impact on the drug pharmacokinetics (Nolin et al (2006) 17(9):2363-7). The hypothesis is that compounds that accumulate in the blood of patients with kidney failure impact the pharmacokinetics such that dosing before or after dialysis produces significantly different blood levels of the drug.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Drug - Fexofenadine

Fexofenadine will be administered to patients.

Additional Information

Official Study Title

The Effect Dialysis on the Pharmacokinetics of Fexofenadine

Clinical Trial ID

NCT03078777

ParticipAid ID

xbol3d