“Race, Natriuretic Peptides and Physiological Perturbations”
The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.
Exercise capacity VO2 max determination
Each participant's maximal oxygen capacity will be determined using a modified Bruce treadmill protocol.
Dietary Supplement - Standardized meals
Participants will consume the standardized study diet for 3 days provided by the clinical research unit's metabolic kitchen (at UAB).
Each participant will walk at 70 % of his/her VO2max for 20 minutes on treadmill.
Drug - Metoprolol Succinate ER
Each participant will receive metoprolol succinate starting at 50mg/day, titrated bi-weekly up to 200 mg/day for total duration of 6 weeks.
Racial Differences in the Natriuretic Peptide Response to Exercise and Beta-blockers