Socioemotional Processing in Alcohol Use Disorder

Eligibility Details: - INCLUSION CRITERIA: Stage 1: INCLUSION CRITERIA: 1. 21 to 65 years old 2. Physically healthy 3. Healthy volunteers only: Consuming on average 7 or less standard drinks/week if female; 14 or less standard drinks/week if male (as determined by the most recent measurement within the past 90 days Alcohol Timeline Followback) 4. AUD participants only: Diagnosed with current moderate to severe alcohol use disorder according to most recent SCID 5 diagnosis EXCLUSION CRITERIA: 1. Significant history of head trauma or cranial surgery 2. History of neurological disease based on self-report and neuromotor physical exam, conducted by a health care provider, that would interfere with neuroimaging research. Posthoc, clinical MRI scans done according to NIH Clinical Center policy may be reviewed and if there is evidence from that scan of past or current neuroabnormalities that, in the PI or MAI s expert opinion, interfere with research neuroimaging data, the subject may be excluded from data analysis. 3. Healthy volunteers only: Have fulfilled DSM-5 criteria for a current substance or alcohol use disorder 4. Female participants only: Currently pregnant 5. Presence of any contraindication for fMRI as determined by the NIAAA MRI Safety Screening Questionnaire of the screening protocol 14-AA-0181 6. History of non-substance related psychosis 7. Lack of experience with alcohol (defined as less than 3 lifetime drinks reported in history and physical or on Lifetime Drinking History) Stage 2: INCLUSION CRITERIA: 1. 21 to 65 years old 2. Physically healthy 3. Inpatient currently seeking treatment for alcohol use disorder EXCLUSION CRITERIA: 1. Significant history of head trauma or cranial surgery, 2. History of neurological disease based on self-report and neuromotor physical exam, conducted by a health care provider, that would interfere with neuroimaging research. 3. Presence of any contraindication for fMRI as determined by the NIAAA MRI Safety Screening Questionnaire of the screening protocol 14-AA-0181 4. History of non-substance related psychosis 5. Female participants only: Currently pregnant